Medically reviewed by Dr Tapan Patel
Last reviewed: 22nd February 2026
What are Polynucleotides?
Polynucleotides are long chains of nucleotides, which are the basic components of DNA and RNA.
These molecules are known for their regenerative abilities, boosting skin rejuvenation at a cellular level by increasing collagen and elastin production. These proteins are essentials for maintaining skin structure and elasticity, which tend to decrease with age.
Benefits of Polynucleotide Treatments
Polynucleotide treatments at PHI Clinic enhance skin hydration, elasticity, and firmness by activating internal processes, offering a natural alternative to traditional fillers. These treatments stimulate collagen production, improving overall skin appearance.
Polynucleotide treatments in London Clinic
Polynucleotide treatments at PHI Clinic provide a holistic approach to skin rejuvenation, addressing volume loss, fine lines, stretch marks, and skin tone irregularities through natural regeneration. Administered with utmost care, these treatments promote rejuvenated skin and improved structure for lasting results.
The initial consultation is important to evaluate the skin health and setting realistic expectations. It begins with a professional assessment of skin condition and goals, followed by a detailed analysis to determine treatment suitability and create a tailored plan based on individual skin needs. Before injections, a topical anaesthetic minimises discomfort, and precise administration of polynucleotides stimulates collagen and elastin production for enhanced skin elasticity and texture.
Patients are monitored for immediate side effects post-treatment and provided with recovery guidelines, allowing most to resume daily activities shortly after. Post-treatment recovery guidance includes care instructions for optimal outcomes, with follow-up appointments ensuring progress monitoring.
Your Polynucleotides practitioners
Where on the face can you have Polynucleotide?
Typically, polynucleotide treatments target facial areas susceptible to signs of ageing, such as fine lines, wrinkles, and diminished elasticity. These key treatment zones include the cheeks, forehead, around the eyes (crow's feet), and areas affected by scars or pigment irregularities. Additionally, Polynucleotide treatments can be used on the body for specific rejuvenation purposes, targeting areas where skin texture, firmness, or hydration needs improvement.
Are Polynucleotide treatments better than Profhilo?
When comparing Polynucleotide treatments to Profhilo, both offer distinct benefits in skin rejuvenation. Polynucleotides excel in enhancing skin hydration, elasticity, and firmness through their regenerative properties, stimulating natural collagen production. They target specific ageing concerns such as fine lines, wrinkles, and uneven skin tone, providing a comprehensive approach to skin revitalisation.
On the other hand, Profhilo focuses on improving overall skin hydration and firmness with a unique hyaluronic acid formulation, promoting deep tissue hydration and remodelling. The choice between these treatments often depends on individual skin goals and preferences for either collagen stimulation or intense hydration.
When do Polynucleotide treatments show results, and are there any side effects?
Polynucleotide treatments typically show initial results within a few weeks to a month, depending on individual skin response. These treatments activate natural skin processes, stimulating collagen and elastin production for improved hydration and firmness over time. As for side effects, minor redness, swelling, or bruising at the injection sites may occur temporarily. These effects usually resolve within a few days post-treatment, ensuring a smooth recovery process.
Safe and effective treatment
Your safety is our top priority and making our patients feel welcomed and reassured when entering PHI Clinic. To ensure maximum standard of patient care, all of our treatments are only ever carried out by our experienced and highly qualified team, who receive regular in-house and external training from industry experts.
At PHI Clinic we do not offer same day treatment as initial consultation to ensure patients have time to reflect on their bespoke treatment plan before choosing to proceed.
Polynucleotide frequently asked questions
A polynucleotide injectable treatment is a cosmetic procedure that uses polynucleotide injections to stimulate skin regeneration, improving skin quality and elasticity.
Polynucleotide injections boost collagen production, which helps to improve skin elasticity and firmness, reducing the appearance of sagging skin.
Yes, polynucleotide treatments are generally well-tolerated and can be suitable for sensitive skins, but it's essential to consult with a medical practitioner for personalised advice.
Yes, polynucleotide injections can be used to rejuvenate the under-eye area, reducing dark circles and fine lines for a fresher appearance.
Polynucleotide treatments can be combined with other aesthetic treatments like filler products to enhance overall facial features and improve skin texture.
Polynucleotide treatments promote the natural regeneration of skin cells, leading to improved skin texture and overall skin quality.
Polynucleotide injections stimulate collagen and elastin production, leading to smoother skin and reduced appearance of deep lines and dull skin.
Polynucleotide skin rejuvenation treatments should be administered by a qualified medical practitioner to ensure safety and effectiveness.
Yes, most patients can resume their normal activities shortly after a polynucleotide injectable skin treatment, as the procedure involves minimal downtime.
Yes, polynucleotide injections can help to smooth lines and improve the appearance of nasolabial folds by enhancing skin elasticity and hydration.
Location
PHI Clinic
102 Harley Street,
London,
W1G 7JB,
United Kingdom
Tel: 02070345999
Opening Hours
Monday & Tuesday - 9:30am to 6:00pm
Wednesday & Thursday - 9:30am to 8:00pm
Friday - 9:30am to 5:00pm
Saturday - 11:30am to 12:30pm
Sunday - Closed
Opening times can change, if your appointment is outside of these times please contact the clinic for confirmation.
