For more videos, follow PHI Clinic on Instagram @phiclinic
What Are Polynucleotides?
Polynucleotides are injectable biostimulators made from purified fragments of salmon DNA, the natural building blocks of life. Unlike dermal fillers or anti-wrinkle injections, which fill lines or relax muscles, polynucleotide injections in London work at a cellular level to:
- Stimulate fibroblastic cells to drive collagen and elastin production
- Encourage cell regeneration and tissue repair
- Improve skin hydration and elasticity
- Calm inflammation and support the skin's antioxidant defences
- Enhance blood flow and restore the skin barrier
These properties make them well suited to a range of skin problems, including crepey skin, acne scarring, pigmentation, loss of skin elasticity, dullness and under-eye hollows.
How Many Treatments Will I Need?
At PHI Clinic, we typically recommend a course of 2 to 3 polynucleotides in London treatments spaced a few weeks apart. This allows the product to build a strong foundation for long-term skin rejuvenation and improved elasticity.
Each treatment session adds to the regenerative effect. The course matters more than any single appointment, because the results are cumulative rather than immediate.
How Long Do Results Last?
After completing a full course, most patients enjoy results lasting around 6 to 9 months. Key outcomes include:
- Smoother skin with fewer skin tone irregularities
- Reduced appearance of wrinkles and fine lines
- Noticeable improvement in skin hydration and skin texture
Because of the natural degradation rate in areas of the face like the under-eyes, maintenance top-up treatments every 6 months are commonly recommended to hold the result.
What Affects the Longevity of Results?
Several factors influence how long polynucleotide results last:
- Age and skin type. Mature or dehydrated skin may metabolise the product faster.
- Lifestyle factors. UV exposure, stress and smoking all work against collagen production and skin health.
- Treatment area. Areas with thin skin, such as hollows under eyes, tend to break down injectable treatments more quickly.
- Product quality. The grade of product used influences both efficacy and duration.
- Consistency. Regular maintenance amplifies the regenerative benefit rather than starting again from scratch.
Recent clinical reviews have explored the evidence behind polynucleotide efficacy in skin rejuvenation, highlighting their regenerative role in improving hydration, elasticity and dermal repair. A literature review published in Aesthetic Nursing Journal reports promising outcomes in enhancing fibroblast activity and supporting long-term skin regeneration, alongside a strong safety profile.
Your expert practitioner will carry out a skin assessment and review your medical history, then tailor a treatment plan around your aesthetic goals.
Can You Extend the Benefits?
Yes. Following our post-treatment instructions makes a measurable difference to how long the results hold:
- Apply SPF 50 daily to shield the skin from cellular damage and maintain barrier health
- Use skincare with antioxidants and ingredients that support cell turnover, such as retinol and vitamin C
- Prioritise hydration, sleep and nutrition, all of which support healing and skin regeneration
- Avoid harsh cosmetic procedures like chemical peels and ablative lasers in the days after treatment
These habits extend the result and improve your overall skin quality at the same time.
Why Choose Polynucleotides Over Other Aesthetic Treatments?
Polynucleotide treatments in London are increasingly recognised for delivering natural-looking results with long-term skin rejuvenation. Compared with hyaluronic acid fillers or anti-wrinkle injections, these skin boosters:
- Provide deep tissue repair and skin regeneration
- Improve hydration, skin firmness and tone
- Deliver rejuvenating effects without altering facial volume
Profhilo sits somewhere between the two, hydrating and remodelling the skin rather than driving repair at a cellular level, which is why the two are sometimes used alongside each other rather than as alternatives.
That makes polynucleotides particularly suitable for sensitive skin, under-eye rejuvenation, textured skin, acne scars and stretch marks, and for anyone seeking subtle improvement through regenerative aesthetics.
Are There Side Effects?
Polynucleotide injections are generally well tolerated, and most patients report only brief discomfort during treatment. Some experience mild swelling, bruising, small bumps at the injection sites, or redness, particularly in the delicate periorbital area such as the tear trough. These usually resolve within a couple of days, so downtime is minimal.
Patients with a fish allergy should not have this treatment and should speak to their practitioner about alternatives.
Polynucleotides London Consultation
How long polynucleotides last depends on your age, your skin, and the care taken over the course. With the right number of treatment sessions and consistent aftercare, most patients can expect 6 to 9 months of visibly smoother skin, restored hydration and improved elasticity.
At PHI Clinic London, polynucleotides at our London clinic are delivered by experienced aesthetic practitioners who will tell you honestly whether the treatment suits your skin and what results are realistic.
Book your consultation today and we will talk through the course, the likely maintenance schedule and the cost.
