For more videos, follow PHI Clinic on Instagram @phiclinic
What Are Polynucleotides?
Polynucleotides are injectable biostimulators made from purified fragments of salmon DNA the natural building blocks of life. Unlike dermal fillers or anti-wrinkle injections that aim to fill lines or relax muscles, polynucleotide injections work at a cellular level to:
- Stimulate fibroblast cells for the production of collagen and elastin
- Encourage cellular regeneration and tissue repair
- Improve skin hydration and elasticity through hydrating properties
- Calm inflammation and support antioxidant properties
- Enhance blood flow and restore the skin barrier
The unique properties of polynucleotides make them ideal for addressing multiple skin concerns, including crepey skin, loss of skin elasticity, dullness, and hollows under eyes.
When Will I See Results?
Polynucleotide treatments do not deliver instant change instead, they activate your skin’s natural repair mode. Most patients notice subtle improvements in skin glow, texture, and tone 2-3 weeks after their first session.
As the skin health improves through cellular regeneration, more visible improvements in skin hydration, elasticity, and overall skin quality are seen in the weeks after treatment particularly after a full course.
How Many Treatments Will I Need?
At PHI Clinic, we typically recommend a course of 2–3 polynucleotide treatments spaced a few weeks apart. This allows the polynucleotide product to build a strong foundation for long-term skin rejuvenation and improved skin elasticity.
Each treatment session enhances the regenerative effects, delivering healthier, more youthful-looking skin. Polynucleotide injections are considered highly effective injectable treatments with minimal side effects.
How Long Do Results Last?
After completing a full course of 2-3 polynucleotide treatments, most patients enjoy results lasting around 6 to 9 months. Key outcomes include:
- Smoother skin with improved tone
- Reduced appearance of wrinkles and fine lines
- Noticeable improvement in skin hydration and texture
Due to the natural degradation rate in areas like the under-eyes, maintenance top-up treatments every 6 months are commonly recommended to support ongoing skin goals.
What Affects the Longevity of Results?
Several factors can influence the duration of polynucleotide results:
- Age and skin type: Mature skin or dehydrated skin may metabolise the polynucleotide product faster.
- Lifestyle: Exposure to UV rays, stress, and smoking negatively affect collagen production and skin health.
- Treatment area: Areas with thin skin, such as hollows under eyes, may break down injectable skin treatments more quickly.
- Product quality: The quality of products used can significantly influence treatment efficacy and duration.
- Consistency: Regular injectable skin boosters amplify regenerative benefits and skin rejuvenation.
Recent clinical reviews have explored the growing body of evidence behind polynucleotide efficacy in skin rejuvenation, highlighting their regenerative role in improving hydration, elasticity, and dermal repair. According to a literature review published in Aesthetic Nursing Journal, polynucleotides have demonstrated promising outcomes in enhancing fibroblast activity and supporting long-term skin regeneration while maintaining an excellent safety profile.
Your expert practitioner will assess your skin concerns and medical history to tailor a bespoke treatment plan.
Can You Extend the Benefits?
Yes, polynucleotide longevity can be supported with consistent at-home care and clinical guidance:
- Apply SPF 50 daily to shield the skin from cellular damage and maintain barrier health
- Use effective skincare containing antioxidant properties and ingredients that promote cell turnover, such as retinol and vitamin C
- Prioritise hydration, sleep, and nutrition to support skin regeneration and blood flow
- Avoid harsh cosmetic procedures like chemical peels and ablative lasers in the days after treatment
These habits can enhance both the properties of polynucleotides and your overall skin quality.
Why Choose Polynucleotides Over Other Aesthetic Treatments?
Polynucleotide treatments are increasingly recognised for their ability to deliver natural-looking results with long-term skin rejuvenation. Compared to hyaluronic acid-based fillers or anti-wrinkle injections, these injectable treatments:
- Provide deep tissue repair and skin regeneration
- Improve hydration levels, elasticity, and tone
- Offer rejuvenating effects without altering facial volume
This makes polynucleotide injections especially suitable for sensitive skin, under-eye areas, textured skin, stretch marks, and individuals seeking subtle improvements through regenerative aesthetics.
Are There Side Effects?
Polynucleotide injections are generally well tolerated. Some patients may experience mild swelling, small bumps at injection sites, or redness particularly in delicate areas such as the tear trough. These common side effects typically resolve within a couple of days.
However, patients with a fish allergy should avoid this treatment and consult their practitioner for alternative cosmetic procedures.
Polynucleotides London Consultation
How long polynucleotides last ultimately depends on your age, skin condition, and the expertise of your chosen clinic. But with the right number of treatment sessions and ongoing care, you can enjoy 6 to 9 months of visibly smoother skin, restored hydration, and enhanced elasticity.
At PHI Clinic London, we only use polynucleotide products of the highest standard, delivered by industry-leading aesthetic doctors. Whether you're looking to address fine lines, loss of skin elasticity, or achieve a glowing complexion with fewer cosmetic concerns we’re here to help.
Book your consultation today and discover how this powerful skin booster can help achieve your long-term skin goals through tailored, regenerative care.
