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What Are Skin Boosters?
Skin boosters are injectable treatments designed to improve overall skin quality - enhancing hydration, elasticity, and texture - without changing your facial contours.
Unlike traditional fillers, which are used to add volume or structure, skin boosters work at a cellular level to restore skin health and enhance radiance. They are ideal for a wide range of skin types and concerns, and can be used preventatively or as part of a targeted rejuvenation plan. Skin boosters may be right for you if you’re looking to:
- Revive dull or dehydrated skin
- Improve skin smoothness and elasticity
- Brighten your complexion with a natural glow
- Maintain healthy skin without altering facial structure
Common treatment areas include the face, neck, décolletage, and hands, places where the skin often shows early signs of ageing.
What Are Polynucleotides?
Polynucleotides are regenerative injectables made from purified DNA fragments. Rather than adding volume, they stimulate fibroblast activity so the skin rebuilds itself over time, which makes them well suited to delicate or compromised skin.
Our complete guide to polynucleotides covers how they work in full.
- Dark under-eye circles or early signs of thinning skin
- Inflammation or sensitivity, including conditions like rosacea
- Sun damage or acne scarring
- Skin that feels fragile or lacking in density
With anti-inflammatory properties and cellular-level repair, polynucleotides can also complement other aesthetic treatments such as laser and microneedling.
What Is Profhilo?
Profhilo is a groundbreaking injectable made from highly concentrated hyaluronic acid. Unlike dermal fillers that sit in one place to restore volume, Profhilo diffuses throughout the skin to deliver deep, even hydration while also stimulating collagen and elastin production.
If you’re looking to restore radiance and elasticity without altering your facial structure, Profhilo offers a subtle yet effective solution. Profhilo is often recommended for patients looking to:
- Rehydrate dull, crepey, or tired-looking skin
- Improve elasticity and smooth out fine lines
- Achieve a fresh, radiant glow across larger areas
- Gently lift and firm the skin without adding volume
The result is visibly smoother, plumper skin with a natural luminosity that lasts.
Read about how we approach polynucleotide treatment.
Key Differences Between Polynucleotides and Profhilo
While both treatments fall under the umbrella of skin boosters, their formulations, actions, and outcomes are distinctly different. Here’s how they compare:
- Polynucleotides are built around DNA fragments that support cellular repair and regeneration. They target sensitive or compromised skin, offering anti-inflammatory benefits and gradual structural improvement.
- Profhilo is composed of pure hyaluronic acid and works by hydrating the skin from within, helping to restore glow, firmness, and elasticity.
In terms of ideal concerns:
- Polynucleotides are best for treating issues like inflammation, dark circles, scarring, and general skin damage.
- Profhilo is a go-to for deep hydration, dullness, and early skin laxity.
Treatment timelines vary too:
- Polynucleotides are usually performed as a course of 3–4 treatments, spaced 2–3 weeks apart.
- Profhilo typically involves two treatments, spaced four weeks apart.
See how polynucleotides are administered at PHI Clinic.
The Benefits of Polynucleotides
Polynucleotides offer regenerative support that’s particularly suited to sensitive or healing skin. This treatment works below the surface to gradually restore strength, resilience, and balance. Some of the key benefits include:
- Stimulates fibroblasts to encourage collagen production
- Repairs and strengthens skin at a cellular level
- Soothes inflamed or reactive skin
- Supports skin healing following aesthetic treatments
- Improves tone, texture, and skin density over time
Ideal for those looking to rejuvenate delicate areas - such as the under-eyes - or patients managing inflammatory skin conditions.
Explore the results polynucleotides are used to achieve.
The Benefits of Profhilo
Profhilo delivers hydration and rejuvenation without creating volume or definition. It’s the treatment of choice for restoring skin vitality with subtlety and elegance. Patients choose Profhilo for its ability to:
- Deeply hydrate the skin from within
- Smooth fine lines and crepey texture
- Boost elasticity and firmness
- Deliver a luminous, dewy glow
- Rejuvenate broad areas such as the face, neck, or chest
Results are natural and even, making Profhilo a favourite for those seeking low-maintenance, high-impact skin health.
Which Treatment Is Right for You?
The most suitable option depends on your individual skin concerns and goals. During your consultation at PHI Clinic, your practitioner will carry out a detailed assessment to tailor a bespoke plan for your skin. As a general guide:
- Choose Polynucleotides if you have reactive, sensitive, or damaged skin, or if your goal is long-term regeneration and repair.
- Opt for Profhilo if you’re seeking an immediate boost in hydration, glow, and skin elasticity, without adding volume.
Combination treatments are also available and may be recommended to target both surface hydration and deeper skin restoration for comprehensive results.
Compare treatment courses and pricing.
How Long Do Results Last?
Each treatment offers its own timeline, depending on the skin’s response and your overall skin health.
Polynucleotides:
- Gradual improvements begin 2–3 weeks after the first session
- Full results develop over a course of treatments
- Effects can last up to 9 months with good skincare maintenance
Profhilo:
- Visible results typically appear within a week of the second session
- Skin feels smoother and looks brighter
- Results usually last around 6 months
Ongoing maintenance sessions can be scheduled to prolong your results and keep skin at its best.
Discuss which skin booster suits you with our team.
Side Effects and Safety
Both treatments are backed by strong safety profiles when carried out by skilled medical practitioners. Side effects are typically mild and short-lived. You may experience:
- Temporary redness or swelling at the injection site
- Mild tenderness or bruising
- Small raised bumps with Profhilo (which usually resolve within 24–48 hours)
Comprehensive aftercare will be provided, and your practitioner will discuss all possible side effects during your consultation.
Book a consultation to compare both treatments.
Book Your Consultation
Whether your skin needs hydration, regeneration, or a combination of both, PHI Clinic offers advanced solutions tailored to your goals.
Polynucleotides and Profhilo each bring something different to the table - but both can help you achieve naturally healthy, beautifully refreshed skin.
Book a consultation with one of our expert team members today to explore your options and take the first step towards visibly smoother, firmer, and healthier-looking skin.
