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Understanding the Three Injectables
Although all three involve injections, their mechanisms and outcomes are distinct.
- Profhilo improves hydration, elasticity and overall skin quality, functioning as one of the most effective injectable moisturisers within modern skin boosters.
- Polynucleotides support deep repair, collagen stimulation and long term skin regeneration, making them the best known of the regenerative injectables.
- Dermal fillers restore lost volume and define facial contours through targeted filler injection techniques.
Each one targets a different layer and purpose within the skin, which is why they are often combined for the most balanced result.
Profhilo: Hydration, Elasticity and Skin Quality
Profhilo in London is a bio remodelling injectable made with a high concentration of pure hyaluronic acid. Instead of adding volume, it spreads gently beneath the skin and stimulates collagen and elastin production, the two structural proteins that give skin its firmness and bounce.
Profhilo is not a dermal filler, despite often being described as one. It contains hyaluronic acid, as most fillers do, but it is never used to add volume or alter facial shape. That difference is the whole reason the two exist side by side.
At PHI Clinic, Profhilo is often chosen for:
- Fine lines and wrinkles
- Loss of skin elasticity
- Visible dehydration or dullness
- Crepey skin and mild skin laxity on the face, neck or body
Because Profhilo behaves like an advanced skin booster, it is especially effective for patients who notice that their skin no longer feels as smooth or luminous as it once did yet do not want to change their facial shape. Results develop gradually over several weeks and typically last around six months, with maintenance sessions recommended to keep the skin supported and hydrated.
This treatment can complement other aesthetic treatments such as chemical peels or botulinum toxin, forming part of a wider skin rejuvenation plan at our aesthetic clinic.
Polynucleotides: Regeneration and Repair
Polynucleotides in London are made from purified DNA fragments that have a powerful regenerative effect on the skin. They help calm inflammation, encourage cell regeneration and activate the fibroblast cells that drive collagen production. This is why polynucleotide injections have become increasingly popular for both complexion improvement and for delicate areas such as the under-eye region.
Polynucleotide treatment at PHI Clinic is commonly used for:
- Fragile or sensitive skin
- Early signs of ageing
- Fine lines or textural irregularities
- Skin affected by acne or inflammation
- Areas needing strengthening rather than volume
Because they stimulate repair rather than add volume, polynucleotides are also used in the management of acne scars and other scarring, where the aim is to improve the quality of damaged skin tissue rather than to fill it.
They work deeper than hydration alone, driving cellular renewal so the skin behaves more like younger, healthier tissue. Patients often describe their skin as looking firmer, smoother and more resilient over time. Because skin regeneration treatments do not alter facial structure, polynucleotides suit those seeking subtle, natural improvement.
This regenerative approach is especially beneficial for under-eye hollowing, dark circles, and delicate skin conditions that require strengthening rather than volumising.
Dermal Fillers: Structure, Shape and Lift
Dermal fillers are volumising injectables, most commonly hyaluronic acid fillers, used to restore structure and reshape the face. At PHI Clinic, fillers are placed at precise injection sites to enhance natural proportions and soften areas where volume loss has created deeper folds or shadows such as nasolabial folds or marionette lines.
Common treatment areas include:
- Cheeks and mid face
- Lips
- Jawline and chin
- Tear troughs
- Nasolabial and marionette lines
Fillers are highly versatile. They can lift, contour, refine and support the facial structure in a way that topical skincare or hydration treatments cannot achieve. Results are immediate and typically last between twelve and eighteen months depending on the area treated.
For the under-eye area, our practitioners only use tear trough fillers when appropriate, often in combination with polynucleotide injections to support the delicate tissue and enhance the long-term effects of treatment.
How They Differ
The simplest way to understand the difference is this:
- Profhilo improves the quality of the skin.
- Polynucleotides support repair and regeneration.
- Dermal fillers enhance shape and structure.
Profhilo and polynucleotides act on the condition of the skin by improving skin hydration, skin texture, and underlying skin rejuvenation, while fillers influence the contours and overall architecture.
Choosing the Right Treatment for You
Your ideal treatment depends on what you see in the mirror and how you want your skin to look and feel.
Profhilo treatment in London may be the best choice if your main concern is dullness, dehydration or early fine lines. It is a favourite before events thanks to the fresh, luminous look it creates.
Polynucleotides may be recommended if your skin is sensitive, thinning, acne prone or showing signs of inflammation. They are especially helpful in the under-eye region, where skin is delicate and often difficult to treat with traditional fillers.
Dermal fillers are often chosen if you want visible lift or contouring, or if deeper folds are due to volume loss rather than surface texture.
During your consultation at PHI Clinic, your practitioner will assess your facial structure, skin quality, existing skin conditions and goals before recommending the most appropriate approach in line with your broader facial rejuvenation plan.
Can These Treatments Be Combined?
Yes, and often they are. In fact, combining them can produce some of the most natural and harmonious results. Examples include:
- Profhilo for hydration alongside filler for mid face support
- Polynucleotides for strengthening delicate under eye tissue before tear trough fillers
- Profhilo or polynucleotides for the neck or décolletage while fillers address facial contours
This blend of hydration, cellular renewal and structural lift is central to regenerative aesthetics, supporting both short term and long term effects. The aim is to enhance the skin from the inside out, while preserving your natural features and expressions.
The PHI Clinic Approach
At PHI Clinic on Harley Street, injectable treatments are carried out by highly trained practitioners who focus on subtle, elegant and medically led results. Every treatment plan is customised to your anatomy, goals and long term skin health. We encourage a thoughtful approach, giving you time between consultation and treatment so you feel informed and confident in your decision.
Whether you are looking to hydrate, regenerate or sculpt, our team will guide you through a personalised plan that supports your natural features and aligns with the highest standards in aesthetic medicine.
Your Next Step
If you are unsure whether Profhilo, polynucleotides or dermal fillers are right for you, our practitioners can help you understand which treatment will give you the most meaningful, natural looking result.
Book your consultation today.
